Delivering Advanced Therapeutics
Supercritical Fluid Videos
The first video shows a fluid reaching and passing through its critical point. Notice the meniscus disappears as the fluid becomes supercritical, indicating there is no longer a distinction between liquid and gas. The meniscus returns as it is taken back below the critical point. This video was provided by Professor Martyn Poliakoff from the University of Nottingham.
The second video shows what effect supercritical carbon dioxide has on PLGA (a polymer approved by the regulatory agencies for drug delivery). As you will see, as the carbon dioxide becomes supercritical, the polymer liquefies.
The next movie shows a short burst of atomisation of a polymer/drug mixture. By careful nozzle selection and control of the atomisation environment, we can control particle formation and manufacture particles that can be injected through narrow guage needles.